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AIDS
From Chewiki Archive - YouChew:
1% Funny, 99% Hot Gas
A disease caused by overdoing something. It results in your immune system shutting down, and is very funny, unless it is caused by Mama Luigi him/herself.
Octorok AIDS
A little known about form of AIDS that is rumored to be an urban legend around Hyrule. It seems that the only way to get Octorok AIDS is by eating Octorok shit.